CATH Domain 3th5A00

CATH Classification

Level	CATH Code	Description
	3	Alpha Beta
	3.40	3-Layer(aba) Sandwich
	3.40.50	Rossmann fold
	3.40.50.300	P-loop containing nucleotide triphosphate hydrolases

Domain Context

CATH Clusters

Superfamily	P-loop containing nucleotide triphosphate hydrolases
Functional Family	Ras-related C3 botulinum toxin substrate 1

Enzyme Information

UniProtKB Entries (1)

RAC1_HUMAN

Homo sapiens

Ras-related C3 botulinum toxin substrate 1

PDB Structure

PDB	3TH5
External Links	PDBSum Proteopedia
Method	X-RAY DIFFRACTION
Organism
Primary Citation	Exome sequencing identifies recurrent somatic RAC1 mutations in melanoma. Krauthammer, M., Kong, Y., Ha, B.H., Evans, P., Bacchiocchi, A., McCusker, J.P., Cheng, E., Davis, M.J., Goh, G., Choi, M., Ariyan, S., Narayan, D., Dutton-Regester, K., Capatana, A., Holman, E.C., Bosenberg, M., Sznol, M., Kluger, H.M., Brash, D.E., Stern, D.F., Materin, M.A., Lo, R.S., Mane, S., Ma, S., Kidd, K.K., Hayward, N.K., Lifton, R.P., Schlessinger, J., Boggon, T.J., Halaban, R. Nat.Genet.