CATH Classification

Domain Context

CATH Clusters

Superfamily 1.10.260.60
Functional Family Histone-lysine N-methyltransferase, H3 lysine-79 specific

Enzyme Information

2.1.1.43
Histone-lysine N-methyltransferase.
based on mapping to UniProt Q8TEK3
S-adenosyl-L-methionine + L-lysine-[histone] = S-adenosyl-L-homocysteine + N(6)-methyl-L-lysine-[histone].

UniProtKB Entries (1)

Q8TEK3
DOT1L_HUMAN
Homo sapiens
Histone-lysine N-methyltransferase, H3 lysine-79 specific

PDB Structure

PDB 3SX0
External Links
Method X-RAY DIFFRACTION
Organism
Primary Citation
Bromo-deaza-SAH: a potent and selective DOT1L inhibitor.
Yu, W., Smil, D., Li, F., Tempel, W., Fedorov, O., Nguyen, K.T., Bolshan, Y., Al-Awar, R., Knapp, S., Arrowsmith, C.H., Vedadi, M., Brown, P.J., Schapira, M.
Bioorg. Med. Chem.
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