CATH Classification

Domain Context

CATH Clusters

Superfamily Vaccinia Virus protein VP39
Functional Family Mycinamicin VI 2''-O-methyltransferase

Enzyme Information

2.1.1.238
Mycinamicin VI 2''-O-methyltransferase.
based on mapping to UniProt Q83WF2
S-adenosyl-L-methionine + mycinamicin VI = S-adenosyl-L-homocysteine + mycinamicin III.
-!- The enzyme is involved in the biosynthesis of mycinamicin macrolide antibiotics. -!- Requires Mg(2+) for optimal activity.

UniProtKB Entries (1)

Q83WF2
MYCE_MICGR
Micromonospora griseorubida
Mycinamicin VI 2''-O-methyltransferase

PDB Structure

PDB 3SSO
External Links
Method X-RAY DIFFRACTION
Organism
Primary Citation
A new structural form in the SAM/metal-dependent o‑methyltransferase family: MycE from the mycinamicin biosynthetic pathway.
Akey, D.L., Li, S., Konwerski, J.R., Confer, L.A., Bernard, S.M., Anzai, Y., Kato, F., Sherman, D.H., Smith, J.L.
J.Mol.Biol.
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