CATH Classification
| Level | CATH Code | Description |
|---|---|---|
|
3 | Alpha Beta |
|
3.10 | Roll |
|
3.10.170 | Elastase; domain 1 |
|
3.10.170.10 |
Domain Context
CATH Clusters
| Superfamily | 3.10.170.10 |
| Functional Family |
Enzyme Information
| 3.4.24.27 |
Thermolysin.
based on mapping to UniProt P00800
Preferential cleavage: Xaa-|-Leu > Xaa-|-Phe.
-!- A thermostable extracellular metalloendopeptidase containing four calcium ions. -!- Enzymes that may be species variants of thermolysin are reported from Micrococcus caseolyticus and Aspergillus oryzae. -!- Closely related but distinct enzymes are aeromonolysin, pseudolysin, bacillolysin, aureolysin and mycolysin. -!- Belongs to peptidase family M4. -!- Formerly EC 3.4.24.4.
|
UniProtKB Entries (2)
| P00800 |
THER_BACTH
Bacillus thermoproteolyticus
Thermolysin
|
| P82176 |
IMPI_GALME
Galleria mellonella
Inducible metalloproteinase inhibitor protein
|
PDB Structure
| PDB | 3SSB |
| External Links | |
| Method | X-RAY DIFFRACTION |
| Organism | |
| Primary Citation |
Structural evidence for standard-mechanism inhibition in metallopeptidases from a complex poised to resynthesize a Peptide bond.
Angew.Chem.Int.Ed.Engl.
|