CATH Domain 3sheA01

CATH Classification

Level	CATH Code	Description
	3	Alpha Beta
	3.30	2-Layer Sandwich
	3.30.200	Phosphorylase Kinase; domain 1
	3.30.200.20	Phosphorylase Kinase; domain 1

Domain Context

CATH Clusters

Superfamily	Phosphorylase Kinase; domain 1
Functional Family	MAP kinase-activated protein kinase 3

Enzyme Information

2.7.11.1

Non-specific serine/threonine protein kinase.

based on mapping to UniProt Q16644

ATP + a protein = ADP + a phosphoprotein.

-!- This is a heterogeneous group of serine/threonine protein kinases that do not have an activating compound and are either non-specific or their specificity has not been analyzed to date. -!- Formerly EC 2.7.1.37 and EC 2.7.1.70.

UniProtKB Entries (1)

Q16644

MAPK3_HUMAN

Homo sapiens

MAP kinase-activated protein kinase 3

PDB Structure

PDB	3SHE
External Links	PDBSum Proteopedia
Method	X-RAY DIFFRACTION
Organism
Primary Citation	Novel ATP competitive MK2 inhibitors with potent biochemical and cell-based activity throughout the series. Oubrie, A., Kaptein, A., de Zwart, E., Hoogenboom, N., Goorden, R., van de Kar, B., van Hoek, M., de Kimpe, V., van der Heijden, R., Borsboom, J., Kazemier, B., de Roos, J., Scheffers, M., Lommerse, J., Schultz-Fademrecht, C., Barf, T. Bioorg.Med.Chem.Lett.