CATH Domain 3s9zA01

CATH Classification

Level	CATH Code	Description
	3	Alpha Beta
	3.20	Alpha-Beta Barrel
	3.20.20	TIM Barrel
	3.20.20.360	Malate synthase, domain 3

Domain Context

CATH Clusters

Superfamily	Malate synthase, domain 3
Functional Family	Malate synthase G

Enzyme Information

2.3.3.9

Malate synthase.

based on mapping to UniProt P9WK17

Acetyl-CoA + H(2)O + glyoxylate = (S)-malate + CoA.

-!- The enzyme catalyzes the irreversible condensation of acetyl-CoA with glyoxylate to form (S)-malate. -!- Among other functions, the enzyme participates in the glyoxylate cycle, a modified version of the TCA cycle that bypasses steps that lead to a loss of CO(2). -!- Formerly EC 4.1.3.2.

UniProtKB Entries (1)

P9WK17

MASZ_MYCTU

Mycobacterium tuberculosis H37Rv

Malate synthase G

PDB Structure

PDB	3S9Z
External Links	PDBSum Proteopedia
Method	X-RAY DIFFRACTION
Organism
Primary Citation	Structure-guided discovery of phenyl-diketo acids as potent inhibitors of M. tuberculosis malate synthase. Krieger, I.V., Freundlich, J.S., Gawandi, V.B., Roberts, J.P., Gawandi, V.B., Sun, Q., Owen, J.L., Fraile, M.T., Huss, S.I., Lavandera, J.L., Ioerger, T.R., Sacchettini, J.C. Chem.Biol.