CATH Classification
| Level | CATH Code | Description |
|---|---|---|
|
3 | Alpha Beta |
|
3.50 | 3-Layer(bba) Sandwich |
|
3.50.50 | FAD/NAD(P)-binding domain |
|
3.50.50.60 | FAD/NAD(P)-binding domain |
Domain Context
CATH Clusters
| Superfamily | FAD/NAD(P)-binding domain |
| Functional Family | L-ornithine N(5)-monooxygenase |
Enzyme Information
| 1.14.13.195 |
L-ornithine N(5)-monooxygenase (NADPH).
based on mapping to UniProt Q51548
L-ornithine + NADPH + O(2) = N(5)-hydroxy-L-ornithine + NADP(+) + H(2)O.
-!- The enzyme is involved in biosynthesis of N(5)-hydroxy-L-ornithine, N(5)-formyl-N(5)-hydroxy-L-ornithine or N(5)-acetyl-N(5)-hydroxy-L- ornithine. -!- These nonproteinogenic amino acids are building blocks of siderophores produced by some bacteria (e.g. Streptomyces coelicolor, Saccharopolyspora erythraea and Pseudomonas aeruginosa). -!- The enzyme is specific for NADPH. -!- Cf. EC 1.14.13.196.
|
UniProtKB Entries (1)
| Q51548 |
PVDA_PSEAE
Pseudomonas aeruginosa PAO1
L-ornithine N(5)-monooxygenase
|
PDB Structure
| PDB | 3S5W |
| External Links | |
| Method | X-RAY DIFFRACTION |
| Organism | |
| Primary Citation |
Two Structures of an N-Hydroxylating Flavoprotein Monooxygenase: ORNITHINE HYDROXYLASE FROM PSEUDOMONAS AERUGINOSA.
J.Biol.Chem.
|
