CATH Classification
| Level | CATH Code | Description |
|---|---|---|
|
4 | Few Secondary Structures |
|
4.10 | Irregular |
|
4.10.87 | mRNA Capping Enzyme; Chain |
|
4.10.87.10 | mRNA Capping Enzyme; domain 3 |
Domain Context
CATH Clusters
| Superfamily | mRNA Capping Enzyme; domain 3 |
| Functional Family | mRNA-capping enzyme |
Enzyme Information
| 3.1.3.33 |
Polynucleotide 5'-phosphatase.
based on mapping to UniProt O60942
A 5'-phosphopolynucleotide + H(2)O = a polynucleotide + phosphate.
-!- Does not act on nucleoside monophosphates. -!- Induced in Escherichia coli by T-even phages.
|
| 2.7.7.50 |
mRNA guanylyltransferase.
based on mapping to UniProt O60942
GTP + (5')pp-Pur-mRNA = diphosphate + G(5')ppp-Pur-mRNA.
-!- Can modify also synthetic poly(A) and poly(G) to form the structures m(7)G(5')pppAn and m(7)G(5')pppGn.
|
UniProtKB Entries (1)
| O60942 |
MCE1_HUMAN
Homo sapiens
MRNA-capping enzyme
|
PDB Structure
| PDB | 3S24 |
| External Links | |
| Method | X-RAY DIFFRACTION |
| Organism | |
| Primary Citation |
Structure of the guanylyltransferase domain of human mRNA capping enzyme.
Proc.Natl.Acad.Sci.USA
|
