CATH Domain 3rywC00

CATH Classification

Level	CATH Code	Description
	1	Mainly Alpha
	1.10	Orthogonal Bundle
	1.10.600	Farnesyl Diphosphate Synthase
	1.10.600.10	Farnesyl Diphosphate Synthase

Domain Context

CATH Clusters

Superfamily	Farnesyl Diphosphate Synthase
Functional Family

Enzyme Information

UniProtKB Entries (1)

A5K4U6_PLAVS

Plasmodium vivax Sal-1

Farnesyl pyrophosphate synthase, putative

PDB Structure

PDB	3RYW
External Links	PDBSum Proteopedia
Method	X-RAY DIFFRACTION
Organism
Primary Citation	Lipophilic analogs of zoledronate and risedronate inhibit Plasmodium geranylgeranyl diphosphate synthase (GGPPS) and exhibit potent antimalarial activity. No, J.H., de Macedo Dossin, F., Zhang, Y., Liu, Y.L., Zhu, W., Feng, X., Yoo, J.A., Lee, E., Wang, K., Hui, R., Freitas-Junior, L.H., Oldfield, E. Proc.Natl.Acad.Sci.USA