CATH Classification
| Level | CATH Code | Description |
|---|---|---|
|
3 | Alpha Beta |
|
3.20 | Alpha-Beta Barrel |
|
3.20.20 | TIM Barrel |
|
3.20.20.70 | Aldolase class I |
Domain Context
CATH Clusters
| Superfamily | Aldolase class I |
| Functional Family | 2-isopropylmalate synthase |
Enzyme Information
| 2.3.3.13 |
2-isopropylmalate synthase.
based on mapping to UniProt Q9JZG1
Acetyl-CoA + 3-methyl-2-oxobutanoate + H(2)O = (2S)-2-isopropylmalate + CoA.
-!- Formerly EC 4.1.3.12.
|
UniProtKB Entries (1)
| Q9JZG1 |
LEU1_NEIMB
Neisseria meningitidis MC58
2-isopropylmalate synthase
|
PDB Structure
| PDB | 3RMJ |
| External Links | |
| Method | X-RAY DIFFRACTION |
| Organism | |
| Primary Citation |
Removal of the C-terminal regulatory domain of alpha-isopropylmalate synthase disrupts functional substrate binding
Biochemistry
|