CATH Classification
Domain Context
CATH Clusters
| Superfamily | Oxygen-evolving enhancer protein 3 (PsbQ), four-helix up-down bundle |
| Functional Family | Peptidyl-prolyl cis-trans isomerase CYP38, chloroplastic |
Enzyme Information
| 5.2.1.8 |
Peptidylprolyl isomerase.
based on mapping to UniProt Q9SSA5
Peptidylproline (omega=180) = peptidylproline (omega=0).
-!- The first type of this enzyme found proved to be the protein cyclophilin, which binds the immunosuppressant cyclosporin A. -!- Other distinct families of the enzyme exist, one being FK-506 binding proteins (FKBP) and another that includes parvulin from Escherichia coli. -!- The three families are structurally unrelated and can be distinguished by being inhibited by cyclosporin A, FK-506 and 5-hydroxy-1,4-naphthoquinone, respectively.
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UniProtKB Entries (1)
| Q9SSA5 |
CYP38_ARATH
Arabidopsis thaliana
Peptidyl-prolyl cis-trans isomerase CYP38, chloroplastic
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PDB Structure
| PDB | 3RFY |
| External Links | |
| Method | X-RAY DIFFRACTION |
| Organism | |
| Primary Citation |
Crystal structure of Arabidopsis cyclophilin38 reveals a previously uncharacterized immunophilin fold and a possible autoinhibitory mechanism.
Plant Cell
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