CATH Classification
| Level | CATH Code | Description |
|---|---|---|
|
2 | Mainly Beta |
|
2.30 | Roll |
|
2.30.30 | SH3 type barrels. |
|
2.30.30.40 | SH3 Domains |
Domain Context
CATH Clusters
| Superfamily | SH3 Domains |
| Functional Family | Tyrosine-protein kinase |
Enzyme Information
| 2.7.10.2 |
Non-specific protein-tyrosine kinase.
based on mapping to UniProt P08631
ATP + a [protein]-L-tyrosine = ADP + a [protein]-L-tyrosine phosphate.
-!- Unlike EC 2.7.10.1, this protein-tyrosine kinase does not have a transmembrane domain. -!- In the human genome, 32 non-specific protein-tyrosine kinases have been identified and these can be divided into 10 families. -!- Formerly EC 2.7.1.112.
|
UniProtKB Entries (2)
| P08631 |
HCK_HUMAN
Homo sapiens
Tyrosine-protein kinase HCK
|
| P03407 |
NEF_HV1A2
HIV-1 M:B_ARV2/SF2
Protein Nef
|
PDB Structure
| PDB | 3REA |
| External Links | |
| Method | X-RAY DIFFRACTION |
| Organism | |
| Primary Citation |
Molecular design, functional characterization and structural basis of a protein inhibitor against the HIV-1 pathogenicity factor Nef.
PLoS ONE
|
