CATH Classification

Domain Context

CATH Clusters

Superfamily Phosphatidylinositol 3-kinase Catalytic Subunit; Chain A, domain 1
Functional Family

Enzyme Information
Phosphatidylinositol-4,5-bisphosphate 3-kinase.
based on mapping to UniProt P48736
ATP + 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate = ADP + 1-phosphatidyl-1D-myo-inositol 3,4,5-trisphosphate.
-!- This enzyme also catalyzes the phosphorylation of PtdIns4P to PtdIns(3,4)P(2), and of PtdIns to PtdIns3P.
Non-specific serine/threonine protein kinase.
based on mapping to UniProt P48736
ATP + a protein = ADP + a phosphoprotein.
-!- This is a heterogeneous group of serine/threonine protein kinases that do not have an activating compound and are either non-specific or their specificity has not been analyzed to date. -!- Formerly EC and EC

UniProtKB Entries (1)

Homo sapiens
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform

PDB Structure

External Links
Primary Citation
Structure-based design of thienobenzoxepin inhibitors of PI3-kinase.
Staben, S.T., Siu, M., Goldsmith, R., Olivero, A.G., Do, S., Burdick, D.J., Heffron, T.P., Dotson, J., Sutherlin, D.P., Zhu, B.Y., Tsui, V., Le, H., Lee, L., Lesnick, J., Lewis, C., Murray, J.M., Nonomiya, J., Pang, J., Prior, W.W., Salphati, L., Rouge, L., Sampath, D., Sideris, S., Wiesmann, C., Wu, P.