CATH Domain 3r4mA00

CATH Classification

Level	CATH Code	Description
	3	Alpha Beta
	3.30	2-Layer Sandwich
	3.30.565	Heat Shock Protein 90
	3.30.565.10	Histidine kinase-like ATPase, C-terminal domain

Domain Context

CATH Clusters

Superfamily	Histidine kinase-like ATPase, C-terminal domain
Functional Family	Heat shock protein HSP 90-alpha

Enzyme Information

UniProtKB Entries (1)

HS90A_HUMAN

Homo sapiens

Heat shock protein HSP 90-alpha

PDB Structure

PDB	3R4M
External Links	PDBSum Proteopedia
Method	X-RAY DIFFRACTION
Organism
Primary Citation	Optimization of potent, selective, and orally bioavailable pyrrolodinopyrimidine-containing inhibitors of heat shock protein 90. Identification of development candidate 2-amino-4-{4-chloro-2-[2-(4-fluoro-1H-pyrazol-1-yl)ethoxy]-6-methylphenyl}-N-(2,2-difluoropropyl)-5,7-dihydro-6H-pyrrolo[3,4-d]pyrimidine-6-carboxamide. Zehnder, L., Bennett, M., Meng, J., Huang, B., Ninkovic, S., Wang, F., Braganza, J., Tatlock, J., Jewell, T., Zhou, J.Z., Burke, B., Wang, J., Maegley, K., Mehta, P.P., Yin, M.J., Gajiwala, K.S., Hickey, M.J., Yamazaki, S., Smith, E., Kang, P., Sistla, A., Dovalsantos, E., Gehring, M.R., Kania, R., Wythes, M., Kung, P.P. J.Med.Chem.