CATH Domain 3r0iA01

CATH Classification

Level	CATH Code	Description
	3	Alpha Beta
	3.40	3-Layer(aba) Sandwich
	3.40.50	Rossmann fold
	3.40.50.720	NAD(P)-binding Rossmann-like Domain

Domain Context

CATH Clusters

Superfamily	NAD(P)-binding Rossmann-like Domain
Functional Family	1-deoxy-D-xylulose 5-phosphate reductoisomerase

Enzyme Information

1.1.1.267

1-deoxy-D-xylulose-5-phosphate reductoisomerase.

based on mapping to UniProt P45568

2-C-methyl-D-erythritol 4-phosphate + NADP(+) = 1-deoxy-D-xylulose 5-phosphate + NADPH.

-!- The enzyme from several eubacteria, including Escherichia coli, forms part of an alternative nonmevalonate pathway for terpenoid biosynthesis. -!- The mechanism has been shown to be a retroaldol/aldol reaction.

UniProtKB Entries (1)

P45568

DXR_ECOLI

Escherichia coli K-12

1-deoxy-D-xylulose 5-phosphate reductoisomerase

PDB Structure

PDB	3R0I
External Links	PDBSum Proteopedia
Method	X-RAY DIFFRACTION
Organism
Primary Citation	Reverse Fosmidomycin Derivatives against the Antimalarial Drug Target IspC (Dxr). Behrendt, C.T., Kunfermann, A., Illarionova, V., Matheeussen, A., Pein, M.K., Grawert, T., Kaiser, J., Bacher, A., Eisenreich, W., Illarionov, B., Fischer, M., Maes, L., Groll, M., Kurz, T. J.Med.Chem.