CATH Classification
| Level | CATH Code | Description |
|---|---|---|
|
1 | Mainly Alpha |
|
1.25 | Alpha Horseshoe |
|
1.25.40 | Serine Threonine Protein Phosphatase 5, Tetratricopeptide repeat |
|
1.25.40.10 | Tetratricopeptide repeat domain |
Domain Context
CATH Clusters
| Superfamily | Tetratricopeptide repeat domain |
| Functional Family | N-lysine methyltransferase SMYD2 isoform X2 |
Enzyme Information
| 2.1.1.43 |
Histone-lysine N-methyltransferase.
based on mapping to UniProt Q8R5A0
S-adenosyl-L-methionine + L-lysine-[histone] = S-adenosyl-L-homocysteine + N(6)-methyl-L-lysine-[histone].
|
| 2.1.1.- |
Methyltransferases.
based on mapping to UniProt Q8R5A0
|
UniProtKB Entries (1)
| Q8R5A0 |
SMYD2_MOUSE
Mus musculus
N-lysine methyltransferase SMYD2
|
PDB Structure
| PDB | 3QWW |
| External Links | |
| Method | X-RAY DIFFRACTION |
| Organism | |
| Primary Citation |
Crystal structures of histone and p53 methyltransferase SmyD2 reveal a conformational flexibility of the autoinhibitory C-terminal domain.
Plos One
|
