CATH Classification

Domain Context

CATH Clusters

Superfamily 3.90.660.10
Functional Family Renalase isoform 1

Enzyme Information

1.6.3.5
Renalase.
based on mapping to UniProt Q5VYX0
(1) 1,2-dihydro-beta-NAD(P) + H(+) + O(2) = beta-NAD(P)(+) + H(2)O(2). (2) 1,6-dihydro-beta-NAD(P) + H(+) + O(2) = beta-NAD(P)(+) + H(2)O(2).
-!- Renalase, previously thought to be a hormone, is a flavoprotein secreted into the blood by the kidney that oxidizes the 1,2-dihydro- and 1,6-dihydro- isomeric forms of beta-NAD(P)H back to beta- NAD(P)(+). -!- These isomeric forms, generated by nonspecific reduction of beta- NAD(P)(+) or by tautomerization of beta-NAD(P)H, are potent inhibitors of primary metabolism dehydrogenases and pose a threat to normal respiration.

UniProtKB Entries (1)

Q5VYX0
RNLS_HUMAN
Homo sapiens
Renalase

PDB Structure

PDB 3QJ4
External Links
Method X-RAY DIFFRACTION
Organism
Primary Citation
FAD-binding site and NADP reactivity in human renalase: a new enzyme involved in blood pressure regulation
Milani, M., Ciriello, F., Baroni, S., Pandini, V., Canevari, G., Bolognesi, M., Aliverti, A.
J.Mol.Biol.