CATH Classification
| Level | CATH Code | Description |
|---|---|---|
|
3 | Alpha Beta |
|
3.50 | 3-Layer(bba) Sandwich |
|
3.50.50 | FAD/NAD(P)-binding domain |
|
3.50.50.60 | FAD/NAD(P)-binding domain |
Domain Context
CATH Clusters
| Superfamily | FAD/NAD(P)-binding domain |
| Functional Family | Renalase isoform 1 |
Enzyme Information
| 1.6.3.5 |
Renalase.
based on mapping to UniProt Q5VYX0
(1) 1,2-dihydro-beta-NAD(P) + H(+) + O(2) = beta-NAD(P)(+) + H(2)O(2). (2) 1,6-dihydro-beta-NAD(P) + H(+) + O(2) = beta-NAD(P)(+) + H(2)O(2).
-!- Renalase, previously thought to be a hormone, is a flavoprotein secreted into the blood by the kidney that oxidizes the 1,2-dihydro- and 1,6-dihydro- isomeric forms of beta-NAD(P)H back to beta- NAD(P)(+). -!- These isomeric forms, generated by nonspecific reduction of beta- NAD(P)(+) or by tautomerization of beta-NAD(P)H, are potent inhibitors of primary metabolism dehydrogenases and pose a threat to normal respiration.
|
UniProtKB Entries (1)
| Q5VYX0 |
RNLS_HUMAN
Homo sapiens
Renalase
|
PDB Structure
| PDB | 3QJ4 |
| External Links | |
| Method | X-RAY DIFFRACTION |
| Organism | |
| Primary Citation |
FAD-binding site and NADP reactivity in human renalase: a new enzyme involved in blood pressure regulation
J.Mol.Biol.
|
