1 keywords

CATH Domain 3qcfA00

CATH Classification

Level CATH Code Description
Class 3 Alpha Beta
Architecture 3.90 Alpha-Beta Complex
Topology 3.90.190 Protein-Tyrosine Phosphatase; Chain A
Homologous Superfamily 3.90.190.10 Protein tyrosine phosphatase superfamily

Domain Context

CATH Clusters

Superfamily Protein tyrosine phosphatase superfamily
Functional Family receptor-type tyrosine-protein phosphatase gamma isoform X1

Enzyme Information

3.1.3.48
Protein-tyrosine-phosphatase.
based on mapping to UniProt P23470
Protein tyrosine phosphate + H(2)O = protein tyrosine + phosphate.
-!- Dephosphorylates O-phosphotyrosine groups in phosphoproteins, such as the products of EC 2.7.10.2.

UniProtKB Entries (1)

P23470
PTPRG_HUMAN
Homo sapiens
Receptor-type tyrosine-protein phosphatase gamma

PDB Structure

PDB 3QCF
External Links
Method X-RAY DIFFRACTION
Organism
Primary Citation
Small molecule receptor protein tyrosine phosphatase [gamma](RPTP[gamma]) ligands that inhibit phosphatase activity via perturbation of the tryptophan-proline-aspartate (WPD) loop
Sheriff, S., Beno, B.R., Zhai, W., Kostich, W.A., McDonnell, P.A., Kish, K., Goldfarb, V., Gao, M., Kiefer, S.E., Yanchunas, J., Huang, Y., Shi, S., Zhu, S., Dzierba, C., Bronson, J., Macor, J.E., Appiah, K.K., Westphal, R.S., O'Connell, J., Gerritz, S.W.
J.Med.Chem.