CATH Classification
Level | CATH Code | Description |
---|---|---|
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2 | Mainly Beta |
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2.40 | Beta Barrel |
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2.40.70 | Cathepsin D, subunit A; domain 1 |
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2.40.70.10 | Acid Proteases |
Domain Context
CATH Clusters
Superfamily | Acid Proteases |
Functional Family | Beta-secretase 1 |
Enzyme Information
3.4.23.46 |
Memapsin 2.
based on mapping to UniProt P56817
Broad endopeptidase specificity. Cleaves Glu-Val-Asn-Leu-|-Asp-Ala-Glu- Phe in the Swedish variant of Alzheimer's amyloid precursor protein.
-!- Suggested to be the major 'beta-secretase' responsible for the cleavage of the beta-amyloid precursor protein to form the amyloidogenic beta-peptide that is implicated in the pathology of Alzheimer's disease. -!- Belongs to peptidase family A1.
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UniProtKB Entries (1)
P56817 |
BACE1_HUMAN
Homo sapiens
Beta-secretase 1
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PDB Structure
PDB | 3QBH |
External Links | |
Method | X-RAY DIFFRACTION |
Organism | |
Primary Citation |
Structure based design, synthesis and SAR of cyclic hydroxyethylamine (HEA) BACE-1 inhibitors.
Bioorg.Med.Chem.Lett.
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