CATH Classification
| Level | CATH Code | Description |
|---|---|---|
|
3 | Alpha Beta |
|
3.30 | 2-Layer Sandwich |
|
3.30.930 | BirA Bifunctional Protein; domain 2 |
|
3.30.930.10 | Bira Bifunctional Protein; Domain 2 |
Domain Context
CATH Clusters
| Superfamily | Bira Bifunctional Protein; Domain 2 |
| Functional Family |
Enzyme Information
| 6.2.1.n2 |
Amino acid--[acyl-carrier-protein] ligase.
based on mapping to UniProt Q89VT8
ATP + an amino acid + [acyl-carrier-protein] = AMP + diphosphate + an aminoacyl-[acyl-carrier-protein].
-!- Catalyzes the ATP-dependent activation of L-alanine, and to a lesser extent of L-glycine and L-serine, and their transfer to the phosphopantetheine prosthetic group covalently attached to a vicinal carrier protein. -!- May participate in nonribosomal peptide synthesis or related processes. -!- L-proline and L-glutamate are very poor substrates whereas D-amino acids are not substrates for ATP-dependent activation. -!- Does not display tRNA aminoacylation activity.
|
UniProtKB Entries (1)
| Q89VT8 |
AACL1_BRADU
Bradyrhizobium diazoefficiens USDA 110
Amino acid--[acyl-carrier-protein] ligase 1
|
PDB Structure
| PDB | 3PZC |
| External Links | |
| Method | X-RAY DIFFRACTION |
| Organism | |
| Primary Citation |
Substrate Recognition by Novel Family of Amino Acid:[Carrier Protein] Ligases
Croatica Chemica Acta
|
