CATH Classification
Level | CATH Code | Description |
---|---|---|
1 | Mainly Alpha | |
1.10 | Orthogonal Bundle | |
1.10.600 | Farnesyl Diphosphate Synthase | |
1.10.600.10 | Farnesyl Diphosphate Synthase |
Domain Context
CATH Clusters
Superfamily | Farnesyl Diphosphate Synthase |
Functional Family | Ent-kaur-16-ene synthase, chloroplastic |
Enzyme Information
4.2.3.17 |
Taxadiene synthase.
based on mapping to UniProt Q41594
Geranylgeranyl diphosphate = taxa-4,11-diene + diphosphate.
-!- This is the committed step in the biosynthesis of the diterpenoid antineoplastic drug Taxol (paclitaxel). -!- The cyclization involves a 1,5-hydride shift.
|
UniProtKB Entries (1)
Q41594 |
TASY_TAXBR
Taxus brevifolia
Taxadiene synthase
|
PDB Structure
PDB | 3P5R |
External Links | |
Method | X-RAY DIFFRACTION |
Organism | |
Primary Citation |
Taxadiene synthase structure and evolution of modular architecture in terpene biosynthesis.
Nature
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