CATH Classification
| Level | CATH Code | Description |
|---|---|---|
|
1 | Mainly Alpha |
|
1.10 | Orthogonal Bundle |
|
1.10.600 | Farnesyl Diphosphate Synthase |
|
1.10.600.10 | Farnesyl Diphosphate Synthase |
Domain Context
CATH Clusters
| Superfamily | Farnesyl Diphosphate Synthase |
| Functional Family | Ent-kaur-16-ene synthase, chloroplastic |
Enzyme Information
| 4.2.3.17 |
Taxadiene synthase.
based on mapping to UniProt Q41594
Geranylgeranyl diphosphate = taxa-4,11-diene + diphosphate.
-!- This is the committed step in the biosynthesis of the diterpenoid antineoplastic drug Taxol (paclitaxel). -!- The cyclization involves a 1,5-hydride shift.
|
UniProtKB Entries (1)
| Q41594 |
TASY_TAXBR
Taxus brevifolia
Taxadiene synthase
|
PDB Structure
| PDB | 3P5P |
| External Links | |
| Method | X-RAY DIFFRACTION |
| Organism | |
| Primary Citation |
Taxadiene synthase structure and evolution of modular architecture in terpene biosynthesis.
Nature
|
