CATH Domain 3p5bP01

CATH Classification

Level	CATH Code	Description
	3	Alpha Beta
	3.30	2-Layer Sandwich
	3.30.70	Alpha-Beta Plaits
	3.30.70.80	Peptidase S8 propeptide/proteinase inhibitor I9

Domain Context

CATH Clusters

Superfamily	Peptidase S8 propeptide/proteinase inhibitor I9
Functional Family	Proprotein convertase subtilisin/kexin type 9

Enzyme Information

3.4.21.-

Serine endopeptidases.

based on mapping to UniProt Q8NBP7

UniProtKB Entries (1)

PCSK9_HUMAN

Homo sapiens

Proprotein convertase subtilisin/kexin type 9

PDB Structure

PDB	3P5B
External Links	PDBSum Proteopedia
Method	X-RAY DIFFRACTION
Organism
Primary Citation	Mechanistic implications for LDL receptor degradation from the PCSK9/LDLR structure at neutral pH. Lo Surdo, P., Bottomley, M.J., Calzetta, A., Settembre, E.C., Cirillo, A., Pandit, S., Ni, Y.G., Hubbard, B., Sitlani, A., Carfi, A. Embo Rep.