CATH Classification
| Level | CATH Code | Description |
|---|---|---|
|
3 | Alpha Beta |
|
3.50 | 3-Layer(bba) Sandwich |
|
3.50.50 | FAD/NAD(P)-binding domain |
|
3.50.50.60 | FAD/NAD(P)-binding domain |
Domain Context
CATH Clusters
| Superfamily | FAD/NAD(P)-binding domain |
| Functional Family | Fumarate reductase flavoprotein subunit |
Enzyme Information
| 1.3.5.4 |
Fumarate reductase (quinol).
based on mapping to UniProt P00363
Succinate + a quinone = fumarate + a quinol.
-!- The enzyme, which is found in anaerobic and facultative organisms such as bacteria, parasitic helminthes, and lower marine organisms, utilizes low potential quinols, such as menaquinol and rhodoquinol, to reduce fumarate as the final step of an anaerobic respiratory chain. -!- The enzyme is known as complex II of the electron transfer chain, similarly to EC 1.3.5.1, to which it is closely related.
|
UniProtKB Entries (1)
| P0AC47 |
FRDB_ECOLI
Escherichia coli K-12
Fumarate reductase iron-sulfur subunit
|
PDB Structure
| PDB | 3P4R |
| External Links | |
| Method | X-RAY DIFFRACTION |
| Organism | |
| Primary Citation |
Geometric restraint drives on- and off-pathway catalysis by the Escherichia coli menaquinol:fumarate reductase.
J.Biol.Chem.
|
