CATH Classification

Domain Context

CATH Clusters

Superfamily 3.40.50.2020
Functional Family Hypoxanthine phosphoribosyltransferase

Enzyme Information

2.4.2.8
Hypoxanthine phosphoribosyltransferase.
based on mapping to UniProt P20035
IMP + diphosphate = hypoxanthine + 5-phospho-alpha-D-ribose 1-diphosphate.
-!- Guanine and 6-mercaptopurine can replace hypoxanthine.
2.4.2.22
Xanthine phosphoribosyltransferase.
based on mapping to UniProt P20035
XMP + diphosphate = 5-phospho-alpha-D-ribose 1-diphosphate + xanthine.

UniProtKB Entries (1)

P20035
HGXR_PLAFG
Plasmodium falciparum FCR-3/Gambia
Hypoxanthine-guanine-xanthine phosphoribosyltransferase

PDB Structure

PDB 3OZF
External Links
Method X-RAY DIFFRACTION
Organism
Primary Citation
Acyclic Immucillin Phosphonates: Second-Generation Inhibitors of Plasmodium falciparum Hypoxanthine- Guanine-Xanthine Phosphoribosyltransferase.
Hazleton, K.Z., Ho, M.C., Cassera, M.B., Clinch, K., Crump, D.R., Rosario, I., Merino, E.F., Almo, S.C., Tyler, P.C., Schramm, V.L.
Chem.Biol.