CATH Classification
Level | CATH Code | Description |
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3 | Alpha Beta |
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3.20 | Alpha-Beta Barrel |
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3.20.20 | TIM Barrel |
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3.20.20.190 | Phosphatidylinositol (PI) phosphodiesterase |
Domain Context
CATH Clusters
Superfamily | Phosphatidylinositol (PI) phosphodiesterase |
Functional Family | 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase |
Enzyme Information
3.1.4.11 |
Phosphoinositide phospholipase C.
based on mapping to UniProt Q01970
1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate + H(2)O = 1D-myo-inositol 1,4,5-trisphosphate + diacylglycerol.
-!- These enzymes form some of the cyclic phosphate Ins(cyclic 1,2)P(4,5)P(2) as well as Ins(1,4,5)P(3). -!- They show activity toward phosphatidylinositol, i.e., the activity of EC 4.6.1.13 in vitro at high calcium concentration.
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UniProtKB Entries (2)
P21279 |
GNAQ_MOUSE
Mus musculus
Guanine nucleotide-binding protein G(q) subunit alpha
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Q01970 |
PLCB3_HUMAN
Homo sapiens
1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-3
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PDB Structure
PDB | 3OHM |
External Links | |
Method | X-RAY DIFFRACTION |
Organism | |
Primary Citation |
Kinetic Scaffolding Mediated by a Phospholipase C-{beta} and Gq Signaling Complex.
Science
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