CATH Domain 3og7A02

CATH Classification

Level	CATH Code	Description
	1	Mainly Alpha
	1.10	Orthogonal Bundle
	1.10.510	Transferase(Phosphotransferase); domain 1
	1.10.510.10	Transferase(Phosphotransferase) domain 1

Domain Context

CATH Clusters

Superfamily	Transferase(Phosphotransferase) domain 1
Functional Family	RAF proto-oncogene serine/threonine-protein kinase

Enzyme Information

2.7.11.1

Non-specific serine/threonine protein kinase.

based on mapping to UniProt P15056

ATP + a protein = ADP + a phosphoprotein.

-!- This is a heterogeneous group of serine/threonine protein kinases that do not have an activating compound and are either non-specific or their specificity has not been analyzed to date. -!- Formerly EC 2.7.1.37 and EC 2.7.1.70.

UniProtKB Entries (1)

P15056

BRAF_HUMAN

Homo sapiens

Serine/threonine-protein kinase B-raf

PDB Structure

PDB	3OG7
External Links	PDBSum Proteopedia
Method	X-RAY DIFFRACTION
Organism
Primary Citation	Clinical efficacy of a RAF inhibitor needs broad target blockade in BRAF-mutant melanoma. Bollag, G., Hirth, P., Tsai, J., Zhang, J., Ibrahim, P.N., Cho, H., Spevak, W., Zhang, C., Zhang, Y., Habets, G., Burton, E.A., Wong, B., Tsang, G., West, B.L., Powell, B., Shellooe, R., Marimuthu, A., Nguyen, H., Zhang, K.Y., Artis, D.R., Schlessinger, J., Su, F., Higgins, B., Iyer, R., D'Andrea, K., Koehler, A., Stumm, M., Lin, P.S., Lee, R.J., Grippo, J., Puzanov, I., Kim, K.B., Ribas, A., McArthur, G.A., Sosman, J.A., Chapman, P.B., Flaherty, K.T., Xu, X., Nathanson, K.L., Nolop, K. Nature