CATH Domain 3n4cA00

Superfamily	Cysteine proteinases
Functional Family	Cathepsin S

3.4.22.27

Cathepsin S.

based on mapping to UniProt P25774

Similar to cathepsin L, but with much less activity on Z-Phe-Arg-|-NHMec, and more activity on the Z-Val-Val-Arg-|-Xaa compound.

-!- A lysosomal cysteine endopeptidase that is unusual among such enzymes for its stability to neutral pH. -!- Belongs to peptidase family C1.

CATS_HUMAN

Homo sapiens

Cathepsin S

PDB	3N4C
External Links	PDBSum Proteopedia
Method	X-RAY DIFFRACTION
Organism
Primary Citation	6-Phenyl-1H-imidazo[4,5-c]pyridine-4-carbonitrile as cathepsin S inhibitors. Cai, J., Baugh, M., Black, D., Long, C., Jonathan Bennett, D., Dempster, M., Fradera, X., Gillespie, J., Andrews, F., Boucharens, S., Bruin, J., Cameron, K.S., Cumming, I., Hamilton, W., Jones, P.S., Kaptein, A., Kinghorn, E., Maidment, M., Martin, I., Mitchell, A., Rankovic, Z., Robinson, J., Scullion, P., Uitdehaag, J.C., Vink, P., Westwood, P., van Zeeland, M., van Berkom, L., Bastiani, M., Meulemans, T. Bioorg.Med.Chem.Lett.