CATH Domain 3n2zB02

CATH Classification

Level	CATH Code	Description
	1	Mainly Alpha
	1.20	Up-down Bundle
	1.20.120	Four Helix Bundle (Hemerythrin (Met), subunit A)
	1.20.120.980	Serine carboxypeptidase S28, SKS domain

Domain Context

CATH Clusters

Superfamily	Serine carboxypeptidase S28, SKS domain
Functional Family	lysosomal Pro-X carboxypeptidase

Enzyme Information

3.4.16.2

Lysosomal Pro-Xaa carboxypeptidase.

based on mapping to UniProt P42785

Cleavage of a -Pro-|-Xaa bond to release a C-terminal amino acid.

-!- A lysosomal peptidase active at acidic pH that inactivates angiotensin II. -!- Inhibited by diisopropyl fluorophosphate. -!- Belongs to peptidase family S28. -!- Formerly EC 3.4.12.4.

UniProtKB Entries (1)

P42785

PCP_HUMAN

Homo sapiens

Lysosomal Pro-X carboxypeptidase

PDB Structure

PDB	3N2Z
External Links	PDBSum Proteopedia
Method	X-RAY DIFFRACTION
Organism
Primary Citation	Structural definition and substrate specificity of the S28 protease family: the crystal structure of human prolylcarboxypeptidase. Soisson, S.M., Patel, S.B., Abeywickrema, P.D., Bryne, N.J., Diehl, R.E., Hall, D.L., Ford, R.E., Reid, J.C., Rickert, K.W., Shipman, J.M., Sharma, S., Lumb, K.J. Bmc Struct.Biol.