CATH Classification
Level | CATH Code | Description |
---|---|---|
3 | Alpha Beta | |
3.10 | Roll | |
3.10.450 | Nuclear Transport Factor 2; Chain: A, | |
3.10.450.40 |
Domain Context
CATH Clusters
Superfamily | 3.10.450.40 |
Functional Family | Amine oxidase |
Enzyme Information
1.4.3.22 |
Diamine oxidase.
based on mapping to UniProt P19801
Histamine + H(2)O + O(2) = (imidazol-4-yl)acetaldehyde + NH(3) + H(2)O(2).
-!- A group of enzymes that oxidize diamines, such as histamine, and also some primary monoamines but have little or no activity toward secondary and tertiary amines. -!- They are copper quinoproteins (2,4,5-trihydroxyphenylalanine quinone) and, like EC 1.4.3.21 but unlike EC 1.4.3.4, they are sensitive to inhibition by carbonyl-group reagents, such as semicarbazide. -!- Formerly EC 1.4.3.6.
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UniProtKB Entries (1)
P19801 |
AOC1_HUMAN
Homo sapiens
Amiloride-sensitive amine oxidase [copper-containing]
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PDB Structure
PDB | 3MPH |
External Links | |
Method | X-RAY DIFFRACTION |
Organism | |
Primary Citation |
Correlation of active site metal content in human diamine oxidase with trihydroxyphenylalanine quinone cofactor biogenesis
Biochemistry
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