CATH Classification
| Level | CATH Code | Description |
|---|---|---|
|
3 | Alpha Beta |
|
3.30 | 2-Layer Sandwich |
|
3.30.70 | Alpha-Beta Plaits |
|
3.30.70.20 |
Domain Context
CATH Clusters
| Superfamily | 3.30.70.20 |
| Functional Family |
Enzyme Information
| 1.8.99.5 |
Dissimilatory sulfite reductase.
based on mapping to UniProt Q59110
(1) Hydrogen sulfide + a [DsrC protein]-disulfide + 2 acceptor + 3 H(2)O = sulfite + a [DsrC protein]-dithiol + 2 reduced acceptor + 2 H(+). (2) A [DsrC protein]-S-sulfanyl-L-cysteine + 3 acceptor + 3 H(2)O = sulfite + a [DsrC protein]-disulfide + 3 reduced acceptor + 2 H(+).
-!- The enzyme is essential in prokaryotic sulfur-based energy metabolism, including sulfate/sulfite reducing organisms, sulfur- oxidizing bacteria, and organosulfonate reducers. -!- In sulfur reducers it catalyzes the reduction of sulfite to sulfide, while in sulfur oxidizers it catalyzes the opposite reaction. -!- The reaction involves the small protein DsrC, which is present in all the organisms that contain dissimilatory sulfite reductase. -!- During the process an intramolecular disulfide bond is formed between two L-cysteine residues of DsrC. -!- This disulfide can be reduced by a number of proteins including DsrK and TcmB. -!- This enzyme is different from EC 1.8.1.2 and EC 1.8.7.1, which are involved in sulfate assimilation.
|
UniProtKB Entries (1)
| Q59109 |
DSRA_ARCFU
Archaeoglobus fulgidus DSM 4304
Sulfite reductase, dissimilatory-type subunit alpha
|
PDB Structure
| PDB | 3MMC |
| External Links | |
| Method | X-RAY DIFFRACTION |
| Organism | |
| Primary Citation |
Structure of the dissimilatory sulfite reductase from the hyperthermophilic archaeon Archaeoglobus fulgidus.
J.Mol.Biol.
|
