CATH Classification
| Level | CATH Code | Description |
|---|---|---|
|
3 | Alpha Beta |
|
3.40 | 3-Layer(aba) Sandwich |
|
3.40.50 | Rossmann fold |
|
3.40.50.300 | P-loop containing nucleotide triphosphate hydrolases |
Domain Context
CATH Clusters
| Superfamily | P-loop containing nucleotide triphosphate hydrolases |
| Functional Family | Deoxycytidine kinase |
Enzyme Information
| 2.7.1.74 |
Deoxycytidine kinase.
based on mapping to UniProt P27707
NTP + deoxycytidine = NDP + dCMP.
-!- Cytosine arabinoside can act as acceptor; all natural nucleoside triphosphates (except dCTP) can act as donors.
|
UniProtKB Entries (1)
| P27707 |
DCK_HUMAN
Homo sapiens
Deoxycytidine kinase
|
PDB Structure
| PDB | 3MJR |
| External Links | |
| Method | X-RAY DIFFRACTION |
| Organism | |
| Primary Citation |
The Sugar Ring of the Nucleoside Is Required for Productive Substrate Positioning in the Active Site of Human Deoxycytidine Kinase (dCK): Implications for the Development of dCK-Activated Acyclic Guanine Analogues.
J.Med.Chem.
|