CATH Classification
| Level | CATH Code | Description |
|---|---|---|
|
3 | Alpha Beta |
|
3.90 | Alpha-Beta Complex |
|
3.90.79 | Nucleoside Triphosphate Pyrophosphohydrolase |
|
3.90.79.10 | Nucleoside Triphosphate Pyrophosphohydrolase |
Domain Context
CATH Clusters
| Superfamily | Nucleoside Triphosphate Pyrophosphohydrolase |
| Functional Family | diphosphoinositol polyphosphate phosphohydrolase 1 |
Enzyme Information
| 3.6.1.52 |
Diphosphoinositol-polyphosphate diphosphatase.
based on mapping to UniProt Q8NFP7
Diphospho-myo-inositol polyphosphate + H(2)O = myo-inositol polyphosphate + phosphate.
-!- This enzyme hydrolyzes the diphosphate bond, leaving a phospho group where a diphospho group had been. -!- It can also act on bis(adenosine) diphosphate.
|
| 3.6.1.60 |
Diadenosine hexaphosphate hydrolase (AMP-forming).
based on mapping to UniProt Q8NFP7
(1) P(1),P(6)-bis(5'-adenosyl)hexaphosphate + H(2)O = adenosine 5'-pentaphosphate + AMP. (2) P(1),P(5)-bis(5'-adenosyl)pentaphosphate + H(2)O = adenosine 5'-tetraphosphate + AMP.
-!- A divalent cation is essential for activity. -!- Mn(2+) (2-6 mM) is most effective. -!- The enzyme controls intracellular levels of P(1),P(5)- bis(5'-adenosyl)pentaphosphate and P(1),P(6)- bis(5'-adenosyl)hexaphosphate. -!- Weak activity with P(1),P(4)-bis(5'-adenosyl)tetraphosphate. -!- Marked preference for adenine over guanine nucleotides.
|
UniProtKB Entries (1)
| Q8NFP7 |
NUD10_HUMAN
Homo sapiens
Diphosphoinositol polyphosphate phosphohydrolase 3-alpha
|
PDB Structure
| PDB | 3MCF |
| External Links | |
| Method | X-RAY DIFFRACTION |
| Organism | |
| Primary Citation |
Crystal structure of human diphosphoinositol polyphosphate phosphohydrolase 3-alpha
To be Published
|
