CATH Classification
| Level | CATH Code | Description |
|---|---|---|
|
1 | Mainly Alpha |
|
1.20 | Up-down Bundle |
|
1.20.920 | Histone Acetyltransferase; Chain A |
|
1.20.920.10 | Bromodomain-like |
Domain Context
CATH Clusters
| Superfamily | Bromodomain-like |
| Functional Family | Histone-lysine N-methyltransferase |
Enzyme Information
| 2.1.1.43 |
Histone-lysine N-methyltransferase.
based on mapping to UniProt Q03164
S-adenosyl-L-methionine + L-lysine-[histone] = S-adenosyl-L-homocysteine + N(6)-methyl-L-lysine-[histone].
|
UniProtKB Entries (1)
| Q03164 |
KMT2A_HUMAN
Homo sapiens
Histone-lysine N-methyltransferase 2A
|
PDB Structure
| PDB | 3LQJ |
| External Links | |
| Method | X-RAY DIFFRACTION |
| Organism | |
| Primary Citation |
Pro isomerization in MLL1 PHD3-bromo cassette connects H3K4me readout to CyP33 and HDAC-mediated repression.
Cell(Cambridge,Mass.)
|
