CATH Classification

Domain Context

CATH Clusters

Superfamily Ricin (A Subunit), domain 2
Functional Family Antiviral protein I

Enzyme Information

3.2.2.22
rRNA N-glycosylase.
based on mapping to UniProt P84853
Endohydrolysis of the N-glycosidic bond at one specific adenosine on the 28S rRNA.
-!- Ricin A-chain and related toxins show this activity. -!- Naked rRNA is attacked more slowly than rRNA in intact ribosomes. -!- Naked rRNA from Escherichia coli is cleaved at a corresponding position.

UniProtKB Entries (1)

P84853
RIPL1_PHYDI
Phytolacca dioica
Ribosome-inactivating protein PD-L1/PD-L2

PDB Structure

PDB 3LE7
External Links
Method X-RAY DIFFRACTION
Organism
Primary Citation
The role of the glycan moiety on the structure-function relationships of PD-L1, type 1 ribosome-inactivating protein from P. dioica leaves
Severino, V., Chambery, A., Di Maro, A., Marasco, D., Ruggiero, A., Berisio, R., Giansanti, F., Ippoliti, R., Parente, A.
Mol Biosyst