CATH Classification
Level | CATH Code | Description |
---|---|---|
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3 | Alpha Beta |
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3.30 | 2-Layer Sandwich |
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3.30.420 | Nucleotidyltransferase; domain 5 |
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3.30.420.40 | ATPase, nucleotide binding domain |
Domain Context
CATH Clusters
Superfamily | 3.30.420.40 |
Functional Family | Heat shock cognate 71 kDa protein |
Enzyme Information
3.6.4.10 |
Non-chaperonin molecular chaperone ATPase.
based on mapping to UniProt P11021
ATP + H(2)O = ADP + phosphate.
-!- This is a highly diverse group of enzymes that perform many functions that are similar to those of chaperonins. -!- They comprise a number of heat-shock-cognate proteins. -!- They are also active in clathrin uncoating and in the oligomerization of actin.
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UniProtKB Entries (1)
P11021 |
BIP_HUMAN
Homo sapiens
Endoplasmic reticulum chaperone BiP
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PDB Structure
PDB | 3LDO |
External Links | |
Method | X-RAY DIFFRACTION |
Organism | |
Primary Citation |
Adenosine-Derived Inhibitors of 78 kDa Glucose Regulated Protein (Grp78) ATPase: Insights into Isoform Selectivity.
J.Med.Chem.
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