CATH Domain 3ldoA02

CATH Classification

Level	CATH Code	Description
	3	Alpha Beta
	3.30	2-Layer Sandwich
	3.30.30	Defensin A-like
	3.30.30.30

Domain Context

CATH Clusters

Superfamily	3.30.30.30
Functional Family	heat shock 70 kDa protein-like

Enzyme Information

3.6.4.10

Non-chaperonin molecular chaperone ATPase.

based on mapping to UniProt P11021

ATP + H(2)O = ADP + phosphate.

-!- This is a highly diverse group of enzymes that perform many functions that are similar to those of chaperonins. -!- They comprise a number of heat-shock-cognate proteins. -!- They are also active in clathrin uncoating and in the oligomerization of actin.

UniProtKB Entries (1)

P11021

BIP_HUMAN

Homo sapiens

Endoplasmic reticulum chaperone BiP

PDB Structure

PDB	3LDO
External Links	PDBSum Proteopedia
Method	X-RAY DIFFRACTION
Organism
Primary Citation	Adenosine-Derived Inhibitors of 78 kDa Glucose Regulated Protein (Grp78) ATPase: Insights into Isoform Selectivity. Macias, A.T., Williamson, D.S., Allen, N., Borgognoni, J., Clay, A., Daniels, Z., Dokurno, P., Drysdale, M.J., Francis, G.L., Graham, C.J., Howes, R., Matassova, N., Murray, J.B., Parsons, R., Shaw, T., Surgenor, A.E., Terry, L., Wang, Y., Wood, M., Massey, A.J. J.Med.Chem.