1 keywords

CATH Domain 3kvwA01

CATH Classification

Level CATH Code Description
Class 3 Alpha Beta
Architecture 3.30 2-Layer Sandwich
Topology 3.30.10 Trypsin Inhibitor V; Chain A
Homologous Superfamily 3.30.10.30 DYRK

Domain Context

CATH Clusters

Superfamily DYRK
Functional Family

Enzyme Information

2.7.12.1
Dual-specificity kinase.
based on mapping to UniProt Q92630
ATP + a protein = ADP + a phosphoprotein.
-!- This family of enzymes can phosphorylate both Ser/Thr and Tyr residues. -!- Formerly EC 2.7.1.37.

UniProtKB Entries (1)

Q92630
DYRK2_HUMAN
Homo sapiens
Dual specificity tyrosine-phosphorylation-regulated kinase 2

PDB Structure

PDB 3KVW
External Links
Method X-RAY DIFFRACTION
Organism
Primary Citation
Crystal Structure of dual-specificity tyrosine phosphorylation regulated kinase 2 (DYRK2) in complex with an indirubin ligand
Filippakopoulos, P., Myrianthopoulos, V., Kritsanida, M., Magiatis, P., Skaltsounis, A.L., Soundararajan, M., Krojer, T., Gileadi, O., Hapka, E., Fedorov, O., Berridge, G., Wang, J., Shrestha, L., Vollmar, M., von Delft, F., Arrowsmith, C.H., Edwards, A., Weigelt, J., Bountra, C., Mikros, E., Knapp, S.
To be Published
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