CATH Domain 3kkjA02

CATH Classification

Level	CATH Code	Description
	3	Alpha Beta
	3.90	Alpha-Beta Complex
	3.90.660	Polyamine Oxidase; Chain A, domain 2
	3.90.660.10

Domain Context

CATH Clusters

Superfamily	3.90.660.10
Functional Family

Enzyme Information

1.6.3.5

Renalase.

based on mapping to UniProt Q888A4

(1) 1,2-dihydro-beta-NAD(P) + H(+) + O(2) = beta-NAD(P)(+) + H(2)O(2). (2) 1,6-dihydro-beta-NAD(P) + H(+) + O(2) = beta-NAD(P)(+) + H(2)O(2).

-!- Renalase, previously thought to be a hormone, is a flavoprotein secreted into the blood by the kidney that oxidizes the 1,2-dihydro- and 1,6-dihydro- isomeric forms of beta-NAD(P)H back to beta- NAD(P)(+). -!- These isomeric forms, generated by nonspecific reduction of beta- NAD(P)(+) or by tautomerization of beta-NAD(P)H, are potent inhibitors of primary metabolism dehydrogenases and pose a threat to normal respiration.

UniProtKB Entries (1)

Q888A4

RNLS_PSESM

Pseudomonas syringae pv. tomato str. DC3000

Renalase

PDB Structure

PDB	3KKJ
External Links	PDBSum Proteopedia
Method	X-RAY DIFFRACTION
Organism
Primary Citation	X-ray structure of P. syringae q888a4 Oxidoreductase at resolution 2.5A, Northeast Structural Genomics Consortium target PsR10 Kuzin, A.P., Chen, Y., Forouhar, F., Vorobiev, S., Acton, T., Ma, L.C., Xiao, R., Montelione, G.T., Hunt, J.F., Tong, T. To be Published