CATH Domain 3kb7A02

CATH Classification

Level	CATH Code	Description
	1	Mainly Alpha
	1.10	Orthogonal Bundle
	1.10.510	Transferase(Phosphotransferase); domain 1
	1.10.510.10	Transferase(Phosphotransferase) domain 1

Domain Context

CATH Clusters

Superfamily	Transferase(Phosphotransferase) domain 1
Functional Family	Serine/threonine-protein kinase PLK

Enzyme Information

2.7.11.21

Polo kinase.

based on mapping to UniProt P53350

ATP + a protein = ADP + a phosphoprotein.

-!- The enzyme associates with the spindle pole during mitosis and is thought to play an important role in the dynamic function of the mitotic spindle during chromosome segregation. -!- The human form of the enzyme, Plk1, does not phosphorylate histone H1, enolase and phosvitin but it can phosphorylate myelin basic protein and microtubule-associated protein MAP-2, although to a lesser extent than casein. -!- Formerly EC 2.7.1.37.

UniProtKB Entries (1)

P53350

PLK1_HUMAN

Homo sapiens

Serine/threonine-protein kinase PLK1

PDB Structure

PDB	3KB7
External Links	PDBSum Proteopedia
Method	X-RAY DIFFRACTION
Organism
Primary Citation	Identification of 4,5-dihydro-1H-pyrazolo[4,3-h]quinazoline derivatives as a new class of orally and selective Polo-like kinase 1 inhibitors Beria, I., Ballinari, D., Bertrand, J.A., Borghi, D., Bossi, R.T., Brasca, M.G., Cappella, P., Caruso, M., Ceccarelli, W., Ciavolella, A., Cristiani, C., Croci, V., De Ponti, A., Fachin, G., Ferguson, R.D., Lansen, J., Moll, J.K., Pesenti, E., Posteri, H., Perego, R., Rocchetti, M., Storici, P., Volpi, D., Valsasina, B. J.Med.Chem.