CATH Domain 3k5kA00

CATH Classification

Level	CATH Code	Description
	2	Mainly Beta
	2.170	Beta Complex
	2.170.270	Beta-clip-like
	2.170.270.10	SET domain

Domain Context

CATH Clusters

Superfamily	SET domain
Functional Family	Euchromatic histone-lysine N-methyltransferase 2

Enzyme Information

2.1.1.43	Histone-lysine N-methyltransferase. based on mapping to UniProt Q96KQ7 S-adenosyl-L-methionine + L-lysine-[histone] = S-adenosyl-L-homocysteine + N(6)-methyl-L-lysine-[histone].
2.1.1.-	Methyltransferases. based on mapping to UniProt Q96KQ7

UniProtKB Entries (1)

EHMT2_HUMAN

Homo sapiens

Histone-lysine N-methyltransferase EHMT2

PDB Structure

PDB	3K5K
External Links	PDBSum Proteopedia
Method	X-RAY DIFFRACTION
Organism
Primary Citation	Discovery of a 2,4-diamino-7-aminoalkoxyquinazoline as a potent and selective inhibitor of histone lysine methyltransferase G9a. Liu, F., Chen, X., Allali-Hassani, A., Quinn, A.M., Wasney, G.A., Dong, A., Barsyte, D., Kozieradzki, I., Senisterra, G., Chau, I., Siarheyeva, A., Kireev, D.B., Jadhav, A., Herold, J.M., Frye, S.V., Arrowsmith, C.H., Brown, P.J., Simeonov, A., Vedadi, M., Jin, J. J.Med.Chem.