CATH Domain 3jsuA03

CATH Classification

Level	CATH Code	Description
	3	Alpha Beta
	3.30	2-Layer Sandwich
	3.30.572	Thymidylate Synthase; Chain A
	3.30.572.10	Thymidylate synthase/dCMP hydroxymethylase domain

Domain Context

CATH Clusters

Superfamily	Thymidylate synthase/dCMP hydroxymethylase domain
Functional Family	Bifunctional dihydrofolate reductase-thymidylate synthase

Enzyme Information

UniProtKB Entries (1)

D9N170_PLAFA

Plasmodium falciparum

Bifunctional dihydrofolate reductase-thymidylate synthase

PDB Structure

PDB	3JSU
External Links	PDBSum Proteopedia
Method	X-RAY DIFFRACTION
Organism
Primary Citation	Preclinical evaluation of the antifolate QN254, 5-chloro- N'6'-(2,5-dimethoxy-benzyl)-quinazoline-2,4,6-triamine, as an antimalarial drug candidate Nzila, A., Rottmann, M., Chitnumsub, P., Kiara, S.M., Kamchonwongpaisan, S., Maneeruttanarungroj, C., Taweechai, S., Yeung, B.K., Goh, A., Lakshminarayana, S.B., Zou, B., Wong, J., Ma, N.L., Weaver, M., Keller, T.H., Dartois, V., Wittlin, S., Brun, R., Yuthavong, Y., Diagana, T.T. Antimicrob.Agents Chemother.