CATH Domain 3jc6602

CATH Classification

Level	CATH Code	Description
	2	Mainly Beta
	2.40	Beta Barrel
	2.40.50	OB fold (Dihydrolipoamide Acetyltransferase, E2P)
	2.40.50.140	Nucleic acid-binding proteins

Domain Context

CATH Clusters

Superfamily	Nucleic acid-binding proteins
Functional Family	DNA helicase

Enzyme Information

3.6.4.12

DNA helicase.

based on mapping to UniProt P53091

ATP + H(2)O = ADP + phosphate.

-!- DNA helicases utilize the energy from ATP hydrolysis to unwind double-stranded DNA. -!- Some of them unwind duplex DNA with a 3' to 5' polarity (1,3,5,8), other show 5' to 3' polarity (10,11,12,13) or unwind DNA in both directions (14,15). -!- Some helicases unwind DNA as well as RNA (4,9). -!- May be identical with EC 3.6.4.13 (RNA helicase).

UniProtKB Entries (1)

P40359

PSF2_YEAST

Saccharomyces cerevisiae S288C

DNA replication complex GINS protein PSF2

PDB Structure

PDB	3JC6
External Links	PDBSum Proteopedia
Method	ELECTRON MICROSCOPY
Organism
Primary Citation	Structure of the eukaryotic replicative CMG helicase suggests a pumpjack motion for translocation. Yuan, Z., Bai, L., Sun, J., Georgescu, R., Liu, J., O'Donnell, M.E., Li, H. Nat.Struct.Mol.Biol.