CATH Classification
Domain Context
CATH Clusters
| Superfamily | mini-chromosome maintenance (MCM) complex, chain A, domain 1 |
| Functional Family | DNA helicase |
Enzyme Information
| 3.6.4.12 |
DNA helicase.
based on mapping to UniProt P24279
ATP + H(2)O = ADP + phosphate.
-!- DNA helicases utilize the energy from ATP hydrolysis to unwind double-stranded DNA. -!- Some of them unwind duplex DNA with a 3' to 5' polarity (1,3,5,8), other show 5' to 3' polarity (10,11,12,13) or unwind DNA in both directions (14,15). -!- Some helicases unwind DNA as well as RNA (4,9). -!- May be identical with EC 3.6.4.13 (RNA helicase).
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UniProtKB Entries (1)
| P40359 |
PSF2_YEAST
Saccharomyces cerevisiae S288C
DNA replication complex GINS protein PSF2
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PDB Structure
| PDB | 3JC6 |
| External Links | |
| Method | ELECTRON MICROSCOPY |
| Organism | |
| Primary Citation |
Structure of the eukaryotic replicative CMG helicase suggests a pumpjack motion for translocation.
Nat.Struct.Mol.Biol.
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