CATH Classification
| Level | CATH Code | Description |
|---|---|---|
|
2 | Mainly Beta |
|
2.60 | Sandwich |
|
2.60.40 | Immunoglobulin-like |
|
2.60.40.180 | Transthyretin/hydroxyisourate hydrolase domain |
Domain Context
CATH Clusters
| Superfamily | Transthyretin/hydroxyisourate hydrolase domain |
| Functional Family | 5-hydroxyisourate hydrolase |
Enzyme Information
| 3.5.2.17 |
Hydroxyisourate hydrolase.
based on mapping to UniProt Q06S87
5-hydroxyisourate + H(2)O = 5-hydroxy-2-oxo-4-ureido-2,5-dihydro- 1H-imidazole-5-carboxylate.
-!- The reaction is the first stage in the conversion of 5-hydroxyisourate into (S)-allantoin. -!- This reaction will also occur spontaneously, but more slowly.
|
UniProtKB Entries (1)
| Q06S87 |
HIUH_DANRE
Danio rerio
5-hydroxyisourate hydrolase
|
PDB Structure
| PDB | 3IWV |
| External Links | |
| Method | X-RAY DIFFRACTION |
| Organism | |
| Primary Citation |
Probing the evolution of hydroxyisourate hydrolase into transthyretin through active-site redesign.
J.Mol.Biol.
|
