CATH Classification
| Level | CATH Code | Description |
|---|---|---|
|
3 | Alpha Beta |
|
3.20 | Alpha-Beta Barrel |
|
3.20.20 | TIM Barrel |
|
3.20.20.70 | Aldolase class I |
Domain Context
CATH Clusters
| Superfamily | Aldolase class I |
| Functional Family | Homocitrate synthase, mitochondrial |
Enzyme Information
| 2.3.3.14 |
Homocitrate synthase.
based on mapping to UniProt Q9Y823
Acetyl-CoA + H(2)O + 2-oxoglutarate = (R)-2-hydroxybutane-1,2,4- tricarboxylate + CoA.
-!- Belongs in the alpha-aminoadipate pathway of lysine synthesis, along with EC 4.2.1.36. -!- Also acts with oxaloacetate as substrate, but more slowly. -!- Formerly EC 4.1.3.21.
|
UniProtKB Entries (1)
| Q9Y823 |
HOSM_SCHPO
Schizosaccharomyces pombe 972h-
Homocitrate synthase, mitochondrial
|
PDB Structure
| PDB | 3IVT |
| External Links | |
| Method | X-RAY DIFFRACTION |
| Organism | |
| Primary Citation |
Crystal structure and functional analysis of homocitrate synthase, an essential enzyme in lysine biosynthesis.
J.Biol.Chem.
|
