CATH Classification
Level | CATH Code | Description |
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3 | Alpha Beta |
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3.40 | 3-Layer(aba) Sandwich |
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3.40.710 | Beta-lactamase |
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3.40.710.10 | DD-peptidase/beta-lactamase superfamily |
Domain Context
CATH Clusters
Superfamily | DD-peptidase/beta-lactamase superfamily |
Functional Family | D-alanyl-D-alanine serine-type carboxypeptidase |
Enzyme Information
3.4.16.4 |
Serine-type D-Ala-D-Ala carboxypeptidase.
based on mapping to UniProt P08506
Preferential cleavage: (Ac)(2)-L-Lys-D-Ala-|-D-Ala. Also transpeptidation of peptidyl-alanyl moieties that are N-acyl substituents of D-alanine.
-!- A group of bacterial enzymes, membrane-bound. -!- Inhibited by beta-lactam antibiotics, which acylate the active site serine in the enzyme. -!- Distinct from EC 3.4.17.14. -!- Belongs to peptidase families S11, S12 and S13.
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UniProtKB Entries (1)
P08506 |
DACC_ECOLI
Escherichia coli K-12
D-alanyl-D-alanine carboxypeptidase DacC
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PDB Structure
PDB | 3ITA |
External Links | |
Method | X-RAY DIFFRACTION |
Organism | |
Primary Citation |
Crystal structures of penicillin-binding protein 6 from Escherichia coli.
J.Am.Chem.Soc.
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