CATH Domain 3iciB00

CATH Classification

Level	CATH Code	Description
	2	Mainly Beta
	2.40	Beta Barrel
	2.40.100	Cyclophilin
	2.40.100.10	Cyclophilin-like

Domain Context

CATH Clusters

Superfamily	Cyclophilin-like
Functional Family	Peptidyl-prolyl cis-trans isomerase

Enzyme Information

5.2.1.8

Peptidylprolyl isomerase.

based on mapping to UniProt P23284

Peptidylproline (omega=180) = peptidylproline (omega=0).

-!- The first type of this enzyme found proved to be the protein cyclophilin, which binds the immunosuppressant cyclosporin A. -!- Other distinct families of the enzyme exist, one being FK-506 binding proteins (FKBP) and another that includes parvulin from Escherichia coli. -!- The three families are structurally unrelated and can be distinguished by being inhibited by cyclosporin A, FK-506 and 5-hydroxy-1,4-naphthoquinone, respectively.

UniProtKB Entries (2)

E2RA18	CLGN_CANLF Canis lupus familiaris Calmegin
P23284	PPIB_HUMAN Homo sapiens Peptidyl-prolyl cis-trans isomerase B

PDB Structure

PDB	3ICI
External Links	PDBSum Proteopedia
Method	X-RAY DIFFRACTION
Organism
Primary Citation	Structural Basis of Cyclophilin B Binding by the Calnexin/Calreticulin P-domain. Kozlov, G., Bastos-Aristizabal, S., Maattanen, P., Rosenauer, A., Zheng, F., Killikelly, A., Trempe, J.F., Thomas, D.Y., Gehring, K. J.Biol.Chem.