CATH Domain 3hzsA00

CATH Classification

Level	CATH Code	Description
	1	Mainly Alpha
	1.10	Orthogonal Bundle
	1.10.3810	Penicillin binding protein transpeptidase fold
	1.10.3810.10	Biosynthetic peptidoglycan transglycosylase-like

Domain Context

CATH Clusters

Superfamily	Biosynthetic peptidoglycan transglycosylase-like
Functional Family

Enzyme Information

2.4.1.129

Peptidoglycan glycosyltransferase.

based on mapping to UniProt Q7A0I6

(GlcNAc-(1->4)-Mur2Ac(oyl-L-Ala-gamma-D-Glu-L-Lys-D-Ala-D-Ala))(n)- diphosphoundecaprenol + GlcNAc-(1->4)-Mur2Ac(oyl-L-Ala-gamma-D-Glu-L-Lys- D-Ala-D-Ala)-diphosphoundecaprenol = (GlcNAc-(1->4)-Mur2Ac(oyl-L-Ala- gamma-D-Glu-L-Lys-D-Ala-D-Ala))(n+1)-diphosphoundecaprenol + undecaprenyl diphosphate.

-!- The enzyme also works when the lysine residue is replaced by meso- 2,6-diaminoheptanedioate (meso-2,6-diaminopimelate, A2pm) combined with adjacent residues through its L-center, as it is in Gram- negative and some Gram-positive organisms. -!- The undecaprenol involved is ditrans,octacis-undecaprenol. -!- Involved in the synthesis of cell-wall peptidoglycan.

UniProtKB Entries (1)

Q7A0I6

MGT_STAAW

Staphylococcus aureus subsp. aureus MW2

Monofunctional glycosyltransferase

PDB Structure

PDB	3HZS
External Links	PDBSum Proteopedia
Method	X-RAY DIFFRACTION
Organism
Primary Citation	Characterization of the active site of S. aureus monofunctional glycosyltransferase (Mtg) by site-directed mutation and structural analysis of the protein complexed with moenomycin Heaslet, H., Shaw, B., Mistry, A., Miller, A.A. J.Struct.Biol.